Congratulations to Dmitry Sotnikov and the PowerGUI team from Quest Software for winning the "Best of TechEd Breakthrough Product" award at TechEd last week! Being a PowerGUI user myself I can tell you it’s a great tool, especially if you get nervous around a command line.
Coincidentally, Mike Laverick over at RTFM Education has written an excellent whitepaper that details managing VMware with PowerGUI and the VI Toolkit (for Windows). The whitepaper covers everything from installation of all the tools you need to the actual details of managing your VMs. I’m really looking forward to seeing how managing VMware from PowerGUI will get better and better over time.